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| Expression and significance of nerve growth factor in glioma and cerebrospinal fluid |
| LU Xin-Yu, Lu Pei-song, Li Qiao-yu, Yang Yong |
| Department of Neurosurgery ,the Affiliated People’s Hospital of Jiangsu University, Zhenjiang Jiangsu 212002, China |
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Abstract Objective: To study the expression and clinical significance of nerve growth factor(NGF) in glioma and cerebral spinal fluid(CSF). Methods: A total of 86 cases of glioma and CSF were determined for NGF expression by immunohistochemical method(Envision) and ELISA. Ten cases of tissue samples from patients with traumatic brain injury who had received decompression surgery and 10 cases of CSF samples from patients underwent spinal anesthesia without nervous system disease were taken as the corresponding control groups. Results: In glioma and CSF cases，the NGF expression levels was higher than that in corresponding two control groups, the difference was statistically significant(P＜0.05)．There was significant difference in NGF expression between different grades of glioma(P＜0.05)；the expression of NGF increased in parallel with the increase of pathological grade of glioma(P＜0.05); and there was also significant difference in glioma incidence between the supratentorial tumour and infratentorial tumour(P＜0.05). Conclusion: NGF expression was a consistent feature of cerebral tumor, especially in glioma, and its expression was correlated with the genesis and development of glioma.
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Received: 29 June 2012
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2012, Vol. 22 
