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| Significance and expression of β-catenin and MMP-7 in gastric carcinoma
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| LV Cheng-fang1, ZHAO Yuan2,3, WANG Yong-zhong2 |
| (1.Department of Internal Medicine, the Benniu People′s Hospital, Changzhou Jiangsu 213131； 2.School of Clinical Medicine, Jiangsu University, Zhenjiang Jiangsu 212001；3.Department of Surgery,the First People′s Hospital of Zhenjiang, Zhengjiang Jiangsu 212002,China) |
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Abstract Objective: To study expression of β-catenin,MMP-7 and its significance in patients with gastric carcinoma. Methods: The expression of β-catenin in 75 tissue of gastric carcinoma was detected by immunohistochemistry ABC method, and the expriession of MMP-7 in the positive tissue of βcatenin in gastric carcinoma was detected by Western blot. Results: The protein of βcatenin was expressed in 35 of 75 cases in gastric carcinoma, the positive percentage is 46.67%. However, the protein of β-catenin was expressed in 3 of 30 cases in normal gastric tissue, the positive percentage is 10.00%. There was a significant difference in statistical analysis (P<0.05). In addition, The protein of β-catenin was expressed in 44 of 62 cases in patients with lympha node metastasis, the positive percentage was 70.97%. And the positive percentage of β-catenin was 46.15% in patients without lympha node metastasis (P<0.05). The positive rate for β-catenin and MMP-7 were 73.91%, 65.22% respectively in poor-differentiated gastric carcinoma, while they were 47.36%, 42.10% respectively in moderately differentiated gastric carcinoma and 50.00%, 40.00% respectively in well differentiated gastric carcinoma. There was a significant difference in statistical analysis (P<0.05). The positive immunostaining rate for MMP-7 in the area of a positive immunostaining reaction of β-catenin was high in gastric carcinoma (60.00%). The expression of MMP-7 was significantly correlated with β-catenin expression (r＝0.617,P<0.01).Conclusion: The expression of β-catenin, MMP-7 in gastric carcinoma are related to the infiltration and metastasis of gastric carcinoma.
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2012, Vol. 22 
