帕金森病患者粪便钙卫蛋白和乳铁蛋白水平及其与血清IL-6和TNF-α水平的相关性分析

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Abstract Objective： To explore the level of fecal calprotectin (CPT) and lactoferrin (LF) in patients with Parkinson′s disease (PD), and analyze their correlation with clinical symptoms of PD and serum inflammatory factors. Methods： A total of 55 PD patients who first visited the Department of Neurology, the Fourth Affiliated Hospital of Jiangsu University from January 2019 to January 2022 were selected (PD group), and 48 healthy subjects during the same period (control group) were enrolled in the study. The general data of the two groups were collected and compared, and the fecal CPT and LF levels of the two groups as well as the serum tumor cell necrosis factorα (TNFα) and interleukin6 (IL6) levels of the PD group were detected. After 2 months of treatment, fecal CPT and LF levels in the PD group were measured again. The PD group was scored on the Unified Parkinson′s Disease Rating Scale (UPDRS) before and after treatment. Pearson correlation was used to analyze the correlation between fecal CPT, LF levels and UPDRS scores in the PD group, as well as the correlation between ΔCPT, ΔLF and ΔUPDRS scores. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of fecal CPT and LF levels for PD. Results： There were no significant differences in clinical characteristics between PD group and control group (all P>0.05). Before treatment, the fecal levels of CPT and LF in PD group were significantly higher than those in control group (all P<0.01). After treatment, the fecal levels of CPT and LF in PD group, as well as the UPDRS score, were significantly declined compared with those before treatment (all P<0.01). The UPDRS score had a positive correlation with fecal CPT and LF (r=0.605, 0.619, both P<0.01). ΔUPDRS score had a positive correlation with ΔCPT and ΔLF (r=0.735, 0.760, both P<0.01). The fecal CPT and LF levels in PD group before treatment were positively correlated with serum TNF-α and IL-6 respectively (CPT: rTNF-α=0.689, rIL-6=0.591; LF: rTNF-α=0.673, rIL-6=0.616; all P<0.01). The areas under the ROC curves of fecal CPT and LF were 0.892 and 0.874, the sensitivities were 89.58% and 88.32%, and the specificities were 83.29% and 74.55%, respectively. Conclusion： Fecal CPT and LF levels are increased in PD patients, which is correlated with symptom scores and serum TNF-α and IL-6 levels.

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Received: 08 February 2023

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	ZHAO Jing
	SHU Yu
	QIAN Jinjun

Cite this article:

ZHAO Jing,SHU Yu,QIAN Jinjun. Level of fecal calprotectin and lactoferrin in patients with Parkinson′s disease and their correlation with serum IL-6 and TNF-α levels[J]. Journal of Jiangsu University(Medicine Edition), 2024, 34(02): 156-160.

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2024/V34/I02/156

[1]	. [J]. Journal of Jiangsu University(Medicine Edition), 2024, 34(02): 99-103,110.