［2］Kirici P, Kaplan S, Annac E, et al. The effect of Nateglinide and Octreotide on follicular morphology and free radical scavenging system in letrazoleinduced rat model of PCOS［J］. Eur Rev Med Pharmacol Sci, 2022, 26(23): 8893-8902.

［3］Torres PJ, Skarra DV, Ho BS, et al. Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice［J］. BMC Microbiol, 2019, 19(1): 57.

［4］Chapman JC, Min SH, Freeh SM, et al. The estrogeninjected female mouse: new insight into the etiology of PCOS［J］. Reprod Biol Endocrinol, 2009, 7: 47.

［5］Moayeri A, Rostamzadeh A, Raoofi A, et al. Retinoic acid and fibroblast growth factor2 play a key role on modulation of sex hormones and apoptosis in a mouse model of polycystic ovary syndrome induced by estradiol valerate［J］. Taiwan J Obstet Gynecol, 2020, 59(6): 882-890.

［6］Falahatian S, Haddad R, Pakravan N. Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertilityrelated genes in mice model of polycystic ovarian syndrome［J］. J Ovarian Res, 2022, 15(1): 4.

［7］SnchezCriado JE, Bellido C, Galiot F, et al. A possible dual mechanism of the anovulatory action of antiprogesterone RU486 in the rat［J］. Biol Reprod, 1990, 42(5/6): 877-886.

［8］Priyadarshani A, Chuttani K, Mittal G, et al. Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats［J］. J Ovarian Res, 2010, 3: 10.

［9］Lakhani K, Yang W, Dooley A, et al. Aortic function is compromised in a rat model of polycystic ovary syndrome［J］. Hum Reprod, 2006, 21(3): 651-656.

［10］杨艳东. 米非司酮对小鼠卵泡的影响［D］. 广州: 暨南大学, 2008.

［11］付贝贝, 谢青贞. 多囊卵巢综合征动物模型构建方法的研究进展——聚焦于雄激素的诱导［J］. 中国计划生育和妇产科, 2021, 13(12): 12-14.

［12］Edwards DA. Neonatal administration of androstenedione, testosterone or testosterone propionate: effects on ovulation, sexual receptivity and aggressive behavior in female mice［J］. Physiol Behav, 1971, 6(3): 223-228.

［13］胡巧云, 王小丽, 于东升, 等. 西红花酸治疗DHT诱导的PCOS小鼠的机制研究［J］. 现代生物医学进展, 2018, 18(12): 2211-2217.

［14］Maliqueo M, Sun M, Johansson J, et al. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age［J］. Endocrinology, 2013, 154(1): 434-445.

［15］Kauffman AS, Thackray VG, Ryan GE, et al. A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice［J］. Biol Reprod, 2015, 93(3): 69.

［16］Bhattarai P, Rijal S, Bhattarai JP, et al. Suppression of neurotransmission on gonadotropinreleasing hormone neurons in letrozoleinduced polycystic ovary syndrome: A mouse model［J］. Front Endocrinol (Lausanne), 2022, 13: 1059255.

［17］尹萍, 路璐, 陈媛媛, 等. 来曲唑联合45%高脂饲料诱导生殖内分泌及代谢表型异常的多囊卵巢综合征大鼠模型研究［J］. 药学实践杂志, 2019, 37(5): 422-426.

［18］Zhang Y, Zhou H, Ding C. The ameliorative effect of CangFu Daotan Decoction on polycystic ovary syndrome of rodent model is associated with m6A methylation and Wnt/βcatenin pathway［J］. Gynecol Endocrinol, 2023, 39(1): 2181637.

［19］Zheng R, Shen H, Li J, et al. Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo［J］. J Ethnopharmacol, 2023, 301: 115824.

［20］邵华. 人参皂苷对多囊卵巢模型大鼠神经生长因子表达及雄激素水平的影响［D］. 哈尔滨: 黑龙江中医药大学, 2007.

［21］Fazel TF, Chamani M, Khodaei HR, et al. Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression, as a novel component, in a rat model of polycystic ovary syndrome［J］. Iran J Basic Med Sci, 2020, 23(1): 36-45.

［22］严晓南. 宫内高雄激素暴露诱发子代大鼠青春期多囊卵巢综合征的机制研究［D］. 南京: 南京医科大学, 2013.

［23］Manners L, Cajander S, Holmng A, et al. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome［J］. Endocrinology, 2007, 148(8): 3781-3791.

［24］Pruett JE, Everman SJ, Hoang NH, et al. Mitochondrial function and oxidative stress in white adipose tissue in a rat model of PCOS: effect of SGLT2 inhibition［J］. Biol Sex Differ, 2022, 13(1): 45.

［25］van Houten EL, Kramer P, McLuskey A, et al. Reproductive and metabolic phenotype of a mouse model of PCOS［J］. Endocrinology, 2012, 153(6): 2861-2869.

［26］金燕, 王琨, 刘珊珊, 等. 中国汉族女性血清脂联素水平与多囊卵巢综合征关系的Meta分析［J］. 江苏大学学报(医学版), 2015, 25(3): 229-235.

［27］Lee MT, Anderson E, Lee GY. Changes in ovarian morphology and serum hormones in the rat after treatment with dehydroepiandrosterone［J］. Anat Rec, 1991, 231(2): 185-192.

［28］王娜梅. 脱氢表雄酮诱导多囊卵巢综合征大鼠模型的表型研究［J］. 世界中西医结合杂志, 2015, 10(11): 1596-1599.

［29］Yu F, Xue Y, Zhao Y, et al. Isorhamnetin inhibits inflammatory response to alleviate DHEAinduced polycystic ovary syndrome in rats［J］. Gynecol Endocrinol, 2023, 39(1): 2183045.

［30］Zheng S, Chen Y, Ma M, et al. Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats［J］. J Formos Med Assoc, 2022, 121(6): 1081-1092.

［31］张晓薇, 邝健全, 曾爱群, 等. 脱氢表雄酮诱导多囊卵巢综合征动物模型的研究［J］. 广州医学院学报, 2000, 28(3): 14-18.

［32］Solano ME, Sander VA, Ho H, et al. Systemic inflammation, cellular influx and upregulation of ovarian VCAM1 expression in a mouse model of polycystic ovary syndrome (PCOS)［J］. J Reprod Immunol, 2011, 92(1/2): 33-44.

［33］Lai H, Jia X, Yu Q, et al. Highfat diet induces significant metabolic disorders in a mouse model of polycystic ovary syndrome［J］. Biol Reprod, 2014, 91(5): 127.

［34］亓妍妍, 孟欣, 张琳, 等. 多囊卵巢综合征模型的构建与分析［J］. 产业与科技论坛, 2019, 18(1): 56-58.

［35］Poretsky L, Piper B. Insulin resistance, hypersecretion of LH, and a dualdefect hypothesis for the pathogenesis of polycystic ovary syndrome［J］. Obstet Gynecol, 1994, 84(4): 613-621.

［36］徐晓娟, 王婧婧, 姚莉娟, 等. 胰岛素联合HCG改良法建立肥胖型PCOS动物模型评价［J］. 世界科学技术—中医药现代化, 2015, 17(6): 1262-1267.

［37］Hong G, Wu H, Ma ST, et al. Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice［J］. Chin Med, 2020, 15(1): 125.

［38］Demissie M, Lazic M, Foecking EM, et al. Transient prenatal androgen exposure produces metabolic syndrome in adult female rats［J］. Am J Physiol Endocrinol Metab, 2008, 295(2): E262-E268.

［39］Sun F, Yu J. The effect of a special herbal tea on obesity and anovulation in androgensterilized rats［J］. Proc Soc Exp Biol Med, 2000, 223(3): 295-301.

［40］Divyashree S, Janhavi P, Ravindra PV, et al. Experimental models of polycystic ovary syndrome: An update［J］. Life Sci, 2019, 237: 116911.

［41］杜丹峰, 李雪莲. 多囊卵巢综合征动物模型的胰岛素抵抗表现［J］. 国际妇产科学杂志, 2013, 40(1): 24-26.