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| Expression and clinical significance of long non-coding RNA HOTAIR in patients with esophageal squamous cell carcinoma |
| ZHANG Zhao-yue1, YIN Yue1, MOU Xiao1, WU Shi1, MAO Chao-ming2, CHEN De-yu3 |
| (1.School of Clinical Medicine, Jiangsu University, Zhenjiang Jiangsu 212001; 2.Department of Nuclear Medicine, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001; 3.Department of Radiation Oncology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001，China) |
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Abstract Objective: To explore the expression and clinical significance of long non-coding RNA HOTAIR (lncRNA HOTAIR) in esophageal squamous cell carcinoma (ESCC) and analyze its correlation with transforming growth factor β1（TGF-β1）. Methods: Quantitative real-time polymerase chain reaction was used to detect the expressions of HOTAIR mRNA and TGF-β1 mRNA in 57 ESCC tissues and matched tumor-free tissues. The relationship between HOTAIR mRNA and clinico-pathological features of ESCC was also analyzed. Results: In comparison to matched tumor-free tissues, the expressions of HOTAIR mRNA (Z=-2.507，P=0.012) and TGF-β1 mRNA (Z=-2.038，P=0.042) were found to be elevated and lowered, respectively, in ESCC tissues. Up-regulation of HOTAIR expression was correlated with tumor differentiation degree and clinical stage. The expression of HOTAIR was negative correlated with TGF-β1 (r=-0.406，P=0.002). Conclusion: lncRNA HOTAIR in ESCC tissues may play a significant role in the occurrence and development of ESCC through TGF-β1 signaling pathways.
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2014, Vol. 24 
