莫西沙星序贯治疗卫生保健相关性肺炎疗效观察

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Abstract Objective: To evaluate the clinical efficacy of moxifloxacin sequential therapy on patients with healthcareassociated pneumonia(HCAP). Methods: Sixty-two patients with HCAP hospitalized from January 2010 to January 2013 in the emergency ward of Shanghai Gongli Hospital were randomly divided into two groups, the treatment group(n=31) was administrated 0.4 g moxifloxacin intravenously, once a day, took the same medicine orally when the symptoms were improved, with total treatment course of 8~12 d; and the control group(n=31) was administrated 2.0 g cefotiam intravenously, twice a day, with total treatment course of 10~14 d. The efficacy of two groups was compared. Results: The clinical curative effect rates of moxifloxacin and cefotiam were 93.5% and 71.0%, the bacterial clearance rates were 94.7% and 61.1%, respectively; moxifloxacin was better than cefotiam in clinical curative effect(P<0.05). Conclusion: The anti-infection function of moxifloxacin sequential therapy was effective, meanwhile, with high bacterial clearance rate and clinical value.

Received: 14 February 2014

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2014/V24/I02/142

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