Abstract：Objective: To investigate the expressions of aplysia ras homolog Ⅰ(ARHⅠ) and death associated protein kinase(DAPK) in normal brain tissues and glioma tissues and to analyse their clinical pathological significance. Methods: The SP immunohistochemical method was used to detect the expressions of ARHⅠ ans DAPK in 10 case of normal brain tissues and 47 case of human glioma samples. Results: The positive of ARHⅠ and DAPK were the highest in normal brain tissues.In glioma samples of different grades, the expression levels of ARHⅠ and DAPK decreased significantly with the increase of tumor malignancy. There was significant difference in the positive expression of ARHⅠ and DAPK between high grade and low grade glioma tissues.The difference was significant(P<0.05). The expression of ARHⅠ was correlated positively with the expression level of DAPK(r=0.723,P<0.05). Conclusion: The expression of ARHⅠ and DAPK were closely correlated with the clinical pathological grades. The downregulation of ARHⅠ and DAPK was involved in the initiation and progression of glioma.
何瑞1, 2, 袁志诚1, 湛利平1, 李巧玉1. ARHⅠ和DAPK在人脑胶质瘤组织中的表达及意义[J]. 江苏大学学报:医学版, 2012, 22(5): 402-405.
HE Rui-1, 2 , Yuan Zhi-Cheng-1, Zhan Li-Ping-1, Li Qiao-Yu-1. Expression and clinical significance of ARHⅠ and DAPK in Human Glioma. Journal of Jiangsu University(Medicine Edition), 2012, 22(5): 402-405.
2012, Vol. 22 
