Abstract： Objective： To evaluate the efficacy and safety of EndoClot intraoperative hemostatic device for the active bleeding model of heparinized digestive tract ulcer in Bama miniature pigs. Methods： Twelve healthy Bama miniature pigs weighing 40-45 kg were selected and randomly divided into control group ［EndoClot polysaccharide hemostatic system (PHS)］ and experiment group (EndoClotintraoperative hemostatic device), with 6 pigs in each group. The active bleeding model of heparinized digestive tract (upper gastrointestinal tractstomach; lower gastrointestinal tractcolon) was performed. Two ulcer active bleeding wounds were created in each pig, one in each upper and lower digestive tract. The success rate of hemostasis during operation, the time to achieve effective hemostasis, the total amount of hemostatic powder and the wound healing at different time after operation (7, 14, 21, 28 d) were observed and compared between the two groups. Pathological evaluation was performed on stomach, pancreas, lymph nodes, intestinal wounds and brain tissues of the two groups by HE staining. Results： Compared with the control group (11/12, 91.7%), the success rate of hemostasis in the experiment group (12/12, 100.0%) was higher, and the average time to achieve effective hemostasis was shorter and the used amount of hemostatic powder was less, but the differences were not statistically significant (all P>0.05). Compared with the control group, the wound healing score of the experiment group was significantly increased on the 7th and 14th day after surgery (P<0.05), and there was no statistical difference between the two groups on the 21st and 28th day (P>0.05). HE staining showed that no tissue necrosis, foreign body granuloma, ischemia, embolism, capillary hyperplasia, fibrous envelope formation and fat infiltration were observed in the stomach, pancreas, lymph nodes, intestinal wounds and brain in the control group and the experimen group. Conclusion： EndoClot intraoperative hemostatic device could realize the hemostasis of active bleeding of heparinized gastrointestinal ulcer in Bama miniature pigs, which is safe, effective and convenient to operate.
柯其利1， 张恒2， 邢程2， 刘宏飞1. EndoClot术中止血装置治疗巴马小型猪肝素化消化道溃疡活动性出血模型的有效性和安全性[J]. 江苏大学学报:医学版, 2024, 34(02): 145-150.
KE Qili1, ZHANG Heng2, XING Cheng2, LIU Hongfei1. Efficacy and safety of EndoClot intraoperative hemostatic device in Bama miniature pigs heparinized active gastrointestinal ulcer bleeding model
. Journal of Jiangsu University(Medicine Edition), 2024, 34(02): 145-150.
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