Protective effects of PCV-VG combined with PEEP on lungs in patients with lung carcinoma undergoing thoracoscopic radical resection" />
PCV-VG联合PEEP对胸腔镜下行肺癌根治术患者的肺保护作用
Abstract：[Abstract]Objective: To evaluate the effects of pressure controlled ventilationvolume guaranteed (PCVVG) combined with positive endexpiratory pressure (PEEP) on hemodynamics, respiratory mechanics, and oxygenation in patients with pulmonary carcinoma undergoing thoracoscopic radical resection. Methods: Forty patients with lung cancer undwent thoracoscopic lung radical resection were randomly divided into 2 groups: in routine group, both two lung ventilation and one lung ventilation were performed, patients received the ventilation protocol consisting of 8 mL/kg VT, 0 cmH2O PEEP under volume controlled ventilation (VCV), while in combination group, patients received 8 mL/kg VT, PEEP 5 cmH2O under PCVVG. Invasive arterial systolic blood pressure(ASBP) and diastolic blood pressure(ADBP) and heart rate were monitored and recorded at baseline(T0), at the time just before one lung ventilation (T1), at 30 min (T2), 60 min (T3), 120 min after one lung ventilation (T4) and 30 min after the restoration of two lung ventilation (T5). PPeak, PPlat, Cdyn were monitored and recorded at the selected time points, arterial blood samples were collected at T1-T5 time points for blood gases analyse and oxygenation index was calculated. Results: The patterns of hemodynamic parameters were similar between the two groups(P>0.05). Compared with routine group, PPeak, PPlat in combination group were significantly decreased at T2-T5 (P<0.05), while Cdyn, PaO2 and oxygenation index at T1-T5 were significantly higher(P<0.05). Conclusion: PCVVG combined with PEEP could provide stable hemodynamics, improve respiratory mechanics and further increase oxygenation for patients with lung carcinoma undergoing thoracoscopic radical resection.
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