Relationship between DNA fragmentation index of sperm and
outcome of in vitro fertilizationembryo transfer
LI Tian-fu1, XIA Xi-yang1, WEI Hai1, GAO Ting-ting1, LONG Wei2, ZHOU Wen-bo2, CHEN Li1
（1. Center of Reproductive Medicine, 2. Central Laboratory, Affiliated Changzhou Women′s and Children′s Healthcare Hospital of Nanjing Medical University, Changzhou Jiangsu 213003, China)
Abstract：Objective: To investigate the relationship between DNA damage of sperm and outcomes of in vitro fertilizationembryo transfer(IVFET). Methods: We selected 90 couples undergoing the IVFET in the reproductive center of Changzhou Women′s and Children′s Healthcare Hospital. These patients were divided into three groups with DFI values 30％ respectively as normal group,lower damage group and higher damage group. The ages of male and female, semen routine parameters of male, number of ova obtained by female, fertilization rates, cleavage rates, good quality embryo rates, blastocyst formation rates, pregnancy rates and abortion rates were collected and calculated, and then we analyzed the differences among the three groups. Results: There was no significant difference in the ages of male and female, semen routine parameters of male, and numbers of ova in the three groups (P>0.05). There was no statistically significant difference in the rates of fertilization and cleavage between the three groups(P>0.05). Compared with normal group (74.34％±21.56％,31.27％±20.54％), the good quality embryo rates(59.65％±28.93％) and blastocyst formation rates(13.49％±17.74％) of higher damage group were significantly decreased(P0.05). Conclusion: High value of DFI may be associated with lower the good quality embryo rates and blastocyst formation rates, as well as the pregnancy rates, but it is not associated with fertilization rates, cleavage rates and abortion rates.
李天赋1, 夏西洋1, 卫海1, 高亭亭1, 龙伟2, 周文柏2, 陈莉1. 精子DNA碎片化指数与体外受精胚胎移植结局的关系[J]. 江苏大学学报:医学版, 2019, 29(02): 157-160,165.
LI Tian-fu1, XIA Xi-yang1, WEI Hai1, GAO Ting-ting1, LONG Wei2, ZHOU Wen-bo2, CHEN Li1. Relationship between DNA fragmentation index of sperm and
outcome of in vitro fertilizationembryo transfer
. Journal of Jiangsu University(Medicine Edition), 2019, 29(02): 157-160,165.
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2019, Vol. 29 
