Effects of ultralowdose naloxone on analgesia of
dezocine in rats with incisional pain
BAO Yang1, JIAO Ying-fu2, YU Wei-feng2
（1. Department of Anesthesiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800; 2. Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China)
Abstract：Objective: To investigate the effects of ultralowdose naloxone on analgesia of dezocine in rats with incisional pain. Methods: Models of postoperative incision pain (Brennan′s method) in 24 male SD rats were eatablished. Rats were randomly divided into 4 groups(n=6, each group) receiving normal saline, ultralow dose naloxone(1 ng/kg), dezocine(1 mg/kg) and dezocine(1 mg/kg)+naloxone(1 ng/kg) respectively via the tail vein. PWT values in ipsilateral side of hind paws were measured 1 d before surgery, 2 h after surgery, and 1 d, 3 d, 5 d, 7 d after surgery. Results: There were no statistical significance in the PWT values at 1 d, 3 d, 5 d and 7 d among the four groups(P＞0.05). Within each group, compared with baseline, PWT values were significantly decreased on 1 d, and 3 d after surgery, while no difference on 5 d, 7d after surgery(P＜0.01). There was no difference of PWT values between naloxone group and normal saline group(P＞0.05) 2 h after the incision. Dezocine group and dezocine+naloxone group were shown to have significantly higher PWT values than the normal saline group(P<0.01). Dezocine+naloxone group was shown to have significantly higher PWT values than dezocine group (P<0.01). Conclusion: Though ultralow dose of naloxone has no analgesic effect when used alone, it could enhance the analgesic efficacy of dezocine.
收稿日期: 2018-10-25
基金资助:上海健康医学院种子基金资助项目(SFP-18-20-16-002)
通讯作者:
俞卫锋(通讯作者)，主任医师，E-mail: yuweifeng@renji.com
作者简介: 鲍杨(1982—)，女，江苏盐城人，博士，主治医师，主要从事术后镇痛的研究
引用本文:
鲍杨1， 焦英甫2， 俞卫锋2. 超低剂量纳洛酮对地佐辛治疗切口痛模型大鼠术后疼痛效能的影响[J]. 江苏大学学报:医学版, 2019, 29(01): 42-44.
BAO Yang1, JIAO Ying-fu2, YU Wei-feng2. Effects of ultralowdose naloxone on analgesia of
dezocine in rats with incisional pain
. Journal of Jiangsu University(Medicine Edition), 2019, 29(01): 42-44.
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