Abstract：Objective： To study the level and role of advanced glycosylation end products(AGEs) in the modifiedmacular grid photocoagulation for diabetic macular edema(DME). Methods： Normal control group (30 cases),non-proliferative diabetic retinopathy(NPDR) with DME group (26 cases) and proliferative diabetic retinopathy(PDR) with DME group (27 cases) were enrolled in this study. The level of AGEs,central macular thickness (CMT) and the best corrected visual acuity(BCVA) were examined in each group, then the changes of CMT and BCVA before and after the photocoagulation (4，8 weeks) were analyzed. Results： The level of AGEs in NPDR with DME group and PDR with DME group were significant higher than control group（P<0.05）, the level of AGEs in PDR with DME group was higher than NPDR with DME group（P<0.05）. The CMT and BCVA of NPDR with DME group were improved obviously after modifiedmacular grid photocoagulation(4,8 weeks)（all P<0.05）. The CME and BCVA of PDR with DME group had no change after photocoagulation 4 weeks(P＞0.05).After photocoagulation 8 weeks, the CMT of PDR with DME group decreased（P<0.05）, but the BCVA had no improvement(P＞0.05). Conclusion： The increase of AGEs level was closely related to the occurrence and development of DME, massive AGEs formation had great effects on photocoagulation of DME.
［Key words］advanced glycosylation end products; diabetic macular edema; modified grid photocoagulation
基金资助:
江苏大学临床专项基金资助项目（JDLCZX022）
通讯作者:
肖寿华（通讯作者），主任医师，E-mail: eyexiao@sina.com
作者简介: 邱明忠（1977—），男，主治医师
引用本文:
邱明忠, 吕翔, 唐文玲, 邹美波, 肖寿华. 晚期糖基化终末产物对糖尿病黄斑水肿改良格栅样光凝效果的影响[J]. 江苏大学学报:医学版, 2016, 26(06): 529-.
QIU Ming-Zhong, 吕Xiang, Tang-Wen-Ling, Zou-Mei-Bo, Xiao-Shou-Hua. Effect of advanced glycosylation end products on the modified-grid photocoagulation for diabetic macular edema. Journal of Jiangsu University(Medicine Edition), 2016, 26(06): 529-.
2016, Vol. 26 
