Effect of gradual ischemic postconditioning on reperfusion arrhythmia in acute myocardial infarction patients undergoing primary percutaneous coronary intervention triggered by right coronary artery occlusion
Basit BANGASH，YU Zong-liang, XU Hao-jun, ZHU Jian-zhong, GU Ming, ZHOU Wei-wei, WANG Qiang, GU Hui-min
(Department of Cardiology, the Affiliated Kunshan Hospital of Jiangsu University, Kunshan Jiangsu 215300, China)
Abstract：
［Abstract］Objective： To observe the effect of gradual ischemic postconditioning(IP) on reperfusion arrhythmia in patients with acute myocardial infarction(AMI) undergoing primary percutaneous coronary intervention (PCI), which were triggered by right coronary artery occlusion. Methods：A total of 95 patients undergoing primary PCI were randomly divided into three groups after recanalization of occluded right coronary artery：the gradul IP group(n=36) using the angioplasty balloon denation and inflation 1 min/1 min, 30 s/30 s and 15 s/15 s, which performed IP through gradul time within the first minutes of reflow; the IP group(n=35) IP were performed by 3 episodes of denation 1 min and inflation 1 min with the angioplasty balloon; the control group (n=24) undergoing routine PCI. Reperfusion arrhythmia，ST segment regression (SumSTR) ,CKMB and corrected TIMI frame count(CTFC) were analyzed between groups. Results：Incidence of reperfusion arrhythmia and usage of antiarrhythmic drugs were significantly lower in the two IP groups\[ ventricular tachycardia(5.6%,5.7% vs 25.0%,P<0.05),sinus bradycardia(41.7%,45.7% vs 79.2%,P<0.05),usage of antiarrhythmic drugs(11.2%,17.1% vs 41.7%, P<0.05)\]. CTFC\[(24.39±5.21),(25.10±8.72) vs (31.74±8.41), P<0.05\] and values of peaks CKMB \[(91.9±81.2)U/L,(94.1±72.7) U/L vs ( 117.4±81.6) U/L, P<0.05\] were all significantly lower in the two IP groups than in control group while SumSTR\[(57.6±19.5)%, (56.3±17.7)% vs (46.1±22.7)%, P<0.05\] were higher in the two IP groups than control. Conclusion： Right coronary artery occlusion triggered IP can significantly reduce reperfusion arrhythmia in AMI patients undergoing primary PCI. Gradual IP groups had better results than those of IP groups furthermore(P>0.05).
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2016, Vol. 26 
