Comparison of the effects of Fudosteine and N-acetylcysteine on chronic obstructive pulmonary disease complicated with pulmonary fibrosis
BAO Li-juan1 , ZHENG Jin-xu2
(1. Department of Respiration, Jintan Hospital Affiliated to Jiangsu University, Jintan Jiangsu 213200; 2. Department of Respiration, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001, China)
Abstract：Objective: To investigate the effect of long-term oral administration of fudosteine and N-acetylcysteine on chronic obstructive pulmonary disease (COPD) complicated with pulmonary fibrosis. Methods: Each 60 patients with COPD, COPD complicated with pulmonary fibrosis patients and healthy subjects were selected as the COPD-group, the complicated-group and the control-group, respectively. The eight indicators,which were interleukin-1, interleukin-8, laminin, hyaluronic acid, FVC percent predicted (FVC%pred), the first one second forced expiratory volume percent predicted (FEV1%pred), first second vital capacity, forced expiratory volume occupancy percentage (FEV1/FVC), and carbon monoxide diffusing capacity percent predicted (DLCO%pred) in the three groups were detected. The St George′s Respiratory Questionnaire (SGRQ) and high-frequency CT (HRCT) in COPD-group and complicated-group were surveyed and examed. Then the COPD-group and complicated-group were equally randomized into 3 groups respectively, non-intervention-COPD group, fudosteine-COPD-group, N-acetylcysteine-COPD-group, non-intervention-complicated-group, fudosteine-complicated group,N-acetylcysteine-complicated group. Fudosteine group and N-acetylcysteine group were recepted oral adminstration of fudosteine 0.4 g and N-acetylcysteine 0.6 g,respectively, 3 times per day, for six months. The non-intervention-group, fudosteine-group and N-acetylcysteine-group were retested these indicators and examination. Results: Compared with the control group, COPD group and complicated group showed higher levels of interleukin-1, interleukin-8, laminin, hyaluronic acid (P<0.05), which in the complicated group were significantly higher than the COPD group (P<0.05); while with lower levels of FEV1%pred, FVC%pred, FEV1/FVC, DLCO%pred (P<0.01), which in the fudosteine group were significantly lower than the COPD group (P<0.05). Compared with non-interventione group, fudosteine group and N-acetylcysteine group showed higher levels of interleukin-1, interleukin-8, laminin and hyaluronic acid, higher levels of FEV1%pred, FVC%pred, DLCO%pred; meanwhile, quality of life was improved significantly, imaging performed significantly better under HRCT. The changes in fudosteine group were more obvious than in N-acetylcysteine group(P<0.05). Conclusion: Long-term oral administration of fudosteine and N-acetylcysteine could delay the progress of COPD, and improve COPD patients with pulmonary fibrosis. The therapeutic effect of fudosteine was stronger than -acetylcysteine.
收稿日期: 2014-01-03
通讯作者:
郑金旭(通讯作者)，教授，博士生导师，E-mail: jxuzh135@163.com
作者简介: 鲍丽娟( 1983—)，女，江苏金坛人，主治医师，主要从事呼吸内科常见疾病的研究；
引用本文:
鲍丽娟, 郑金旭. 福多司坦与乙酰半胱氨酸对慢性阻塞性肺疾病并发肺纤维化疗效比较[J]. 江苏大学学报:医学版, 2014, 24(04): 333-337.
BAO Li-Juan, ZHENG Jin-Xu. Comparison of the effects of Fudosteine and N-acetylcysteine on chronic obstructive pulmonary disease complicated with pulmonary fibrosis. Journal of Jiangsu University(Medicine Edition), 2014, 24(04): 333-337.
2014, Vol. 24 
