Abstract：Objective: To discuss the expressions and significance of Kip1 ubiquitinationpromoting complex 1（KPC1） and cytoplasmic p27Kip1 in epithelial ovarian cancer. Methods: The expressions of KPC1 and cytoplasmic p27Kip1 in 64 epithelial ovarian cancer samples were detected by immunohistochemical method. The association between their expressions and clinical parameters were analysed. Results: KPC1 and cytoplasmic p27Kip1 expressions were associated with the degree of neoplasm differentiation, FIGO staging and pathological types (both P<0.05). Spearman′s correlation analysis showed KPC1 expression was positively associated with cytoplasmic p27Kip1 (r=0.493,P<0.01). Conclusion: KPC1 and cytoplasmic p27Kip1 might play a synergy role in the oncogenesis and development of ovarian cancer.
收稿日期: 2013-06-05
作者简介: 吴爱民（1970—），女，江苏南通人，副主任医师，主要从事妇产科疾病的研究。
引用本文:
吴爱民， 韩云， 陈燕， 周红. KPC1和胞质p27Kip1在上皮性卵巢癌中的表达及临床意义[J]. 江苏大学学报:医学版, 2013, 23(5): 432-435.
WU Ai-min, HAN Yun, CHEN Yan, ZHOU Hong. Expressions and clinical significance of KPC1 and cytoplasmic p27Kip1 in epithelial ovarian cancer. Journal of Jiangsu University(Medicine Edition), 2013, 23(5): 432-435.
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2013, Vol. 23 
