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Drug and device therapies of congenital longQT syndrome |
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Abstract Congenital longQT syndrome(LQTS) is characterized by the prolongation of QT interval in ECG and relevant torsade de pointes(TdP), which easily leads to sudden cardiac death. Its risk factors include the length of QTc interval, genotype, medical history of syncope, etc. The treatment of congenital LQTS involves β blockers, surgical left cardiac sympathetic denervation(LCSD), cardiac pacing and implantable cardioverter defibrillators(ICD). β blockers are the firstline treatment for all the LQTS patients. Cardiac pacing therapy is fit for LQTS patients complicating bradycardia, which can significantly reduce the recurrence rate of cardiac events, but not the mortality. Highrisk LQTS patients should be implanted with ICD. Less subcutaneous complications of ICD are found and thus the therapy is worthy of being promoted. LCSD is poorly practical and is more suitable for those ICDimplanted patients frequently undergoing electroshock.
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