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Clinical analysis on the changes of ambulatory electrocardiography in 126 patients with thoracic neoplasm after intensity modulated radiation therapy |
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Abstract ObjectiveTo explore the influence of intensity modulated radiation therapy(IMRT) on ambulatory electrocardiography(AECG), for patients with thoracic tumors at different stages, for different types of neoplasms and with different therapies.MethodsOne hundred and twentysix patients with thoracic tumors were enrolled in the research who had accepted IMRT at the Clinical Cancer Center in our hospital.According to the types of neoplasms, they were divided into 3 groups: left lung cancer group(43 cases), left mastocarcinoma group(39 cases) and esophageal cancer group(44 cases).And by the therapies, they were classified into radiotherapy group(36 cases), synchronal chemoradiation group(46 cases) and equential chemoradiation group(44 cases).All groups were monitored by 24hour AECG before, after and half a year after the treatment, and then compared about the abnormity incidence rates of AECG as well as the newly increased rates separately in the above two classifications.ResultsThe incidences of occasional atrial or ventricular arrhythmias and ST-T changes increased significantly after treatment compared with those before, and the differences were statistically significant(P<0.05).There was no statistical significance in the difference of the two AECG indexes before and half a year after therapy(P>0.05).There was also no statistical significance in the differences of newly increased abnormity incidence rates of 3 groups of patients, if we respectively made comparisons among different types of thoracic tumors and different therapies(P>0.05).ConclusionThe AECG changes of patients with thoracic tumors mostly occur at the early stage of IMRT and are reversible.Due to the precision of the therapy, there is no significant difference for different types of thoracic neoplasms in AECG changes after radiotherapy.The chemotherapy combined with Paclitaxel plus Taxanes has less effect on AECG with relatively low cardiac toxicity.
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