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| Analysis of myocardial damage after acute carbon monoxide poisoning in 108 cases |
| KOU Feng-jun，WANG Yue-wen |
| Department of Electrocardiogram, the Second Affiliated Hospital of Xi′an Medical College, Xi′an 710038, China |
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Abstract Objective To study the clinical significance of change of electrocardiogram(ECG), myocardial enzymes and troponin (cTNT) for myocardial damage after acute carbon monoxide poisoning(ACOP). Methods Quantitative clinical observation and retrospective analysis about ECG，myocardial enzymes and cTNT of 108 patients who were diagnosed with ACOP between November 2008 and December 2012 in our hospital were carried out. Results Different degrees of disturbance of consciousness were found among 108 patients. In the observed group, coma was found in 82 cases(75.9%); electrocardiographic abnormality was found in 80 cases (74.1%), including STT change in 69 cases(63.9%). Among 108 ACOP patients, the increase of myocardial enzymes activity was found in 69 cases (63.9%); the increase of cTNT activity in 25 cases (27.8%). The change of ECG, activity increases of myocardial enzymes and cTNT are proportional to the age while has positive relationship with the degree of CO poisoning. There lies significant difference among 3 levels of ACOP. Compared with mild poisoning patients, severe and moderate ones have statistical significant, and so do severe poisoning patients comparing with moderate ones（P<0.01）. After treatment, 101 cases got fully recovered. However, 5 cases died of multiple organs failure and long poisoning time while 2 cases died of delayed encephalopathy after ACOP. Conclusion ACOP can cause myocardial damage in different degrees, which requires appropriate treatment.
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Received: 08 March 2013
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2013, Vol. 22 
