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| Research progress of protective effect of irisin in acute myocardial infarction |
| WANG Yangyang, GU Yunfei, LI Songsen, WANG Hao |
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Abstract Irisin is a hormonelike polypeptide secreted by the muscle tissue, which is generated after hydrolysis of fibronectin type Ⅲ domaincontaining protein 5 by proteolytic enzymes, and released into the peripheral circulation. Irisin plays a potentially protective role in acute myocardial infarction (AMI). This article summarizes the present research progress of the protective effects of irisin in AMI mainly from the following aspects: reducing oxidative stress response, improving mitochondrial function, inhibiting myocardial apoptosis, inhibiting inflammatory response, improving microcirculation, in order to provide valuable references for the diagnosis and treatment of AMI.
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