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| Changes and their significance of serum levels of Wnt-1, DKK-1 and red cell distribution width in patients with coronary heart disease |
| LIU Tongtong, LIN Quanqiang, DONG Shasha, XU Xiuxiu, ZHANG Chen, ZHAO Jian |
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Abstract Objective To explore the correlation between Wnt-1, Dickkopfassociated protein 1 (DKK-1), red cell distribution width (RDW) and coronary heart disease (CHD). To analyze the inherent relationship among Wnt-1, DKK-1 and RDW, and their joint diagnostic value on CHD. Methods We selected 188 inpatients who had undergone coronary angiography (CAG). They were divided into CHD group (n=128) and non-CHD group(n=60) according to CAG results. The clinical data were collected, and the levels of Wnt-1, DKK-1 and RDW were compared between the two groups. Results In the CHD group, the serum level of Wnt-1 decreases while the levels of DKK-1 and RDW increase. There are statistically significant differences of the above indexes between the two groups (P＜0.05). The levels of Wnt-1, DKK-1 and RDW do not vary significantly among the three subgroups of the CHD group, that is, acute myocardial infarction group (30 cases), unstable angina pectoris group (54 cases) and stable angina pectoris group (44 cases) (P＞0.05). Logistic regression analysis reveals that OR values of Wnt-1, DKK-1 and RDW are separately 0.947, 1.023 and 64.995. In the joint diagnosis of CHD, the area under the receiver operating characteristic curve of the three indexes is 0977 (95%CI 0958-0997), with a sensitivity of 92.2% and a specificity of 96.7%. Conclusion DKK-1 and RDW may be independent risk factors for CHD; Wnt-1 is probably its independent protective factor. The joint diagnostic value of Wnt-1, DKK-1 and RDW for CHD is higher than that of any of the above indexes alone.
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