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Abstract Long-term frequent premature ventricular contraction(PVC)(especially>10 000 times/ 24 h) can cause cardiomyopathy, the clinical features of which are similar to those of dilated cardiomyopathy, and myocardial lesions can be reversed after the elimination of PVC. The disease is called PVC-induced cardiomyopathy. Its pathogenesis is not clear, which is possibly related to mechanical heart contraction and asynchronism of electrical excitement resulting in overloaded ventricle, activated neurohumoral mechanism, reduced effective heart pump output, weakened diastolic function and other factors. The load of PVC proves to be the most important factor of cardiomyopathy. At present, diagnostic methods for PVC-induced cardiomyopathy are mostly retrospective diagnosis. If myocardial lesions can be reversed after the elimination of PVC, the diagnosis for PVC-induced cardiomyopathy can be confirmed. Appropriate medication or radiofrequency catheter ablation can reduce and even eliminate PVC, and therefore improve heart function.
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Received: 10 December 2014
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