Abstract：Objective To investigate the factors influencing the decrease of heart rate variability (HRV) in patients with type 2 diabetes mellitus (T2DM). Methods Seventyone inpatients with T2DM were selected as research subjects. According to whether HRV was reduced, these T2DM patients were divided into HRV normal group (39 cases) and HRV reduction group (32 cases). The general data, random blood glucose, HbA1c, triglycerides, cholesterol, LDLC, HDLC, creatinine, uric acid, beta2 microglobulin, urea, and HRV indexes of the two groups were collected. Multivariate Logistic regression analysis was used to study the influencing factors of HRV reduction in T2DM patients. ResultsCompared with the HRV normal group, the patients in the HRV reduction group had longer course of disease, higher levels of random blood glucose, HbA1c, systolic blood pressure, cholesterol and LDLC, and higher proportions of coronary heart disease, diabetic nephropathy, decreased left ventricular diastolic function, STT changes and positive urine glucose as well, all with statistically significant differences (all P<0.05). The values of SDNN, SDANN, rMSSD, pNN50, HRVindex, LF and HF in the HRV reduction group were lower than those in the HRV normal group, and the differences were all statistically significant (all P<0.01). The course of disease, random blood glucose, HbA1c, and coronary heart disease in T2DM patients were independent influencing factors for HRV reduction (P<0.05). Conclusion Timely monitoring and control of the influencing factors for HRV reduction in T2DM patients is conducive to improving the cardiac autonomic function and also has positive significance for improving their prognosis.
