双相障碍躁狂发作患者背外侧前额叶皮质氢质子磁共振波谱研究

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Abstract Objective: To measure the metabolic features of the dorsolateral prefrontal cortex in patients with bipolar mania by using proton magnetic resonance spectroscopy(1H-MRS). Methods: 1H-MRS was performed on dorsolateral prefrontal cortex in 20 unmediated patients with bipolar mania and 20 healthy controls. The levels of N-acetylaspartate(NAA), glutamate/glutamine(Glx) and creatine(Cr) were measured, and ratios of NAA/Cr and Glx/Cr were calculated. The 1H-MRS metabolites levels in dorsolateral prefrontal cortex between patients and healthy controls were compared. The associations between the metabolite levels and the course of disease or the Beth Rafaelsen Mania Scale(BRMS)score were examined. Results: Bipolar mania patients had significantly lower NAA/Cr ratios in bilateral dorsolateral prefrontal cortex than healthy controls, The Glx/Cr ratios from left dorsolateral prefrontal cortex were significantly higher in patients than healthy controls. There were no significant differences in Glx/Cr ratios in right dorsolateral prefrontal cortex between the two groups(P>0.05). There were no significant relationships between all the metabolic indexes and the course of disease or the BRMS score(P>0.05). Conclusion: There might be nerve biochemical dysfunction in the dorsolateral prefrontal cortex of patients with bipolar mania.

Received: 10 November 2012

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2013/V23/I1/42

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