|
|
Effect of rhein on the liver fat content of hyperlipidemia mouse model |
|
|
Abstract Objective: To observe the regulation of rhein on the hyperlipidemia mouse model induced by high fat diet. Methods: The hyperlipidemia mouse models induced by high fat diet were performed successfully and were randomly divided into rhein group (6 mice), model group (6 mice) and control group (6 mice) were normal C57BL/6 mice. After treatment of 8 weeks, growth rate in body weight, food intake, liver fat content, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum creatinine (SCr) were observed. Results: The foodintake in model group and rhein group decreased than those in control group (P<0.01), while there was no significant difference between model group and rhein group (P>0.05). At the end of the experiment, the average weight growth rate in control group was 1.79%, while it was 10.69% in model group and 6.23% in rhubarb group. The average weight growth rate in rhein group was significantly lower than that in model group (P<0.01). The liver fat content is 2.71% in control group, 16.49% in model group, while it was 8.36% in rhubarb group; the liver fat content was significantly lower than that in model group (P<0.01). After treatment, the levels of AST, ALT, and SCr in three groups were no significant differences (P>0.05). Conclusion: Rhein have the function of inhibiting fat deposition in the liver, and the toxic side effects were very low.
|
|
|
|
|
[1] 李晓红,李蒙,陶艳蓉.大黄酸及其衍生物药理作用研究新进展[J]. 现代药物与临床,2010,25(6):417-421.[2] 欧明.冠心病证治与现代研究[M].青岛:青岛出版社,1994:501-505.[3] 周筱琼,于小妹,叶雄伟,等. 高脂血症患者血浆致动脉粥样硬化指数与血栓形成危险因子的相关性[J]. 中国动脉硬化杂志,2010,18(10):799-802.[4] 杨永青,杨公社.大黄酸对大鼠前体脂肪细胞增殖与分化的影响[J].中国药学杂志,2007,42(15):1148-1151.[5] 袁小青,马向华,丁亚琴,等.大黄酸对人前体脂肪细胞增殖与分化的影响[J].南京医科大学学报:自然科学版,2009,29(2):161-165.[6] 刘庆阳,于世家.大黄酸对糖尿病肥胖大鼠脂肪组织抵抗素基因表达及血浆游离脂肪酸水平的影响[J].中华中医药杂志,2009,24(8):1061-1063. |
|
|
|