系统性炎症指标对下肢动脉硬化闭塞症患者发生肌少症的预测价值

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Abstract Objective： To assess the predictive value of systemic inflammatory indicators, including systemic immune-inflammation index (SII), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and C-reactive protein (CRP), for the onset of sarcopenia in patients with lower extremity arteriosclerosis obliterans (ASO). Methods： A total of 251 ASO patients from the Wujin Hospital Affiliated with Jiangsu University and the Second People′s Hospital Affiliated with Nanjing Medical University were included in the study. Patients were classified into sarcopenia and non-sarcopenia groups based on the psoas muscle index (PMI) of the third lumbar vertebra. Relevant blood indicators of the patients were collected, and SII, PLR, NLR, and LMR were calculated. Binary Logistic regression analysis was used to identify the risk factors for sarcopenia, and the predictive performance of each indicator was assessed by using the receiver operating characteristic (ROC) curve. Results： Among the 251 ASO patients, there were 98 (39.0%) in the sarcopenia group and 153 (61.0%) in the non-sarcopenia group. Compared with the non-sarcopenia group, the age of patients in the sarcopenia group was significantly increased (P<0.001), and the levels of SII, PLR, NLR and CRP were significantly increased (P<0.01), and the levels of BMI and LMR were significantly decreased (P<0.01). Multivariate Logistic analysis revealed that advanced age, low BMI, elevated SII were independent risk factors for sarcopenia. The ROC curve further confirmed the predictive value of these indicators for sarcopenia, with the area under the curve (AUC) of age, BMI, SII, and combined prediction of 3 indicators for the onset of sarcopenia being 0.674, 0.678, 0.644, and 0.746 respectively (all P<0.001). Conclusion： Age, BMI, and systemic inflammatory indicators such as SII have predictive value for the onset of sarcopenia in ASO patients.

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Received: 02 September 2023

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	NIE Lu1
	2
	YANG Qifan3
	ZHENG Weimiao1
	2
	XU Qiang1
	2

Cite this article:

NIE Lu1,2,YANG Qifan3等. Predictive value of systemic inflammatory markers for the onset of sarcopenia in patients with lower extremity arteriosclerosis obliterans

[J]. Journal of Jiangsu University(Medicine Edition), 2024, 24(01): 74-78.

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2024/V24/I01/74

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