|
|
|
| Evaluation of the effect of Leucogen on neutropenia in children with influenza virus infection |
| LIU Huan, WANG Suoying, LI Hong |
(Department of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001, China)
|
|
|
|
Abstract Objective： To evaluate the efficacy of Leucogen in the treatment of influenza virus infection with neutropenia in children. Methods： Sixtythree cases of influenza virus infection combined with neutropenia in the Department of Pediatrics, Affiliated Hospital of Jiangsu University from January 2021 to January 2022 were collected. They were randomly divided into the observation group (33 cases) and the control group (30 cases). Eight serum respiratory pathogens, seven throat swab respiratory pathogens, blood routine examination, C-reactive protein, procalcitonin and blood culture were detected in the two groups. On the basis of routine treatment such as antiviral and symptomatic treatment, the observation group was given different doses of Leucogen orally according to ages. The changes of white blood cells and neutrophils were observed at different time points. Results： On the 5th day after treatment, white blood cells and neutrophils of the two groups were significantly higher than those before treatment (both P<0.01). When compared with the control group, the increase of white blood cells and neutrophils in the observation group was more significant after treatment with Leucogen (both P<0.05). When compared with the control group, the total effective rates of white blood cells and neutrophils elevation in the observation group were significantly different after treatment with Leucogen at 3 days, 5 days and 7 days (P<0.01). When compared with the control group, the obvious effect rates of white blood cells and neutrophils elevation were not significant at 3 days after Leucogen treatment, but the obvious effect rates of white blood cells and neutrophils elevation were statistically significant at 5 and 7 days (both P<0.05). Conclusion： After the treatment of influenza virus infection with neutropenia in children, Leucogen could obviously increase leukocytes and neutrophils, and may consequently shorten the window period of secondary bacterial infection.
|
|
Received: 08 October 2022
|
|
|
|
［1］江载芳, 申昆玲, 沈颖. 诸福棠实用儿科学［M］. 8版. 北京: 人民卫生出版社, 2015: 1882-1885.
［2］Husain EH, MullahAli A, AlSharidah S, et al. Infectious etiologies of transient neutropenia in previously healthy children［J］. Pediatr Infect Dis J, 2012, 31(6): 575-577.
［3］Mao H, Liu Y, Sia SF, et al. Avian influenza virus directly infects human natural killer cells and inhibits cell activity［J］. Virol Sin, 2017, 32(2): 122-129.
［4］Callejas Caballero I, Illn Ramos M, Berzosa Snchez A, et al. Autoimmune neutropenia associated with influenza virus infection in childhood: a case report［J］. BMC Infect Dis, 2021, 21(1): 830.
［5］Zhang T, Yin C, Boyd DF, et al. Influenza virus ZRNAs induce ZBP1mediated necroptosis［J］. Cell, 2020, 180(6): 1115-1129.
［6］AtkinSmith GK, Duan M, Chen W, et al. The induction and consequences of influenza A virusinduced cell death［J］. Cell Death Dis, 2018, 9(10): 1002.
［7］Cahilog Z, Zhao H, Wu L, et al. The role of neutrophil NETosis in organ injury: novel inflammatory cell death mechanisms［J］. Inflammation, 2020, 43(6): 2021-2032.
［8］Rada B. Neutrophil extracellular traps［J］. Methods Mol Biol, 2019, 1982: 517-528.
［9］Gu Y, Zuo X, Zhang S, et al. The mechanism behind influenza virus cytokine storm［J］. Viruses, 2021, 13(7): 1362.
［10］Weis S, Te Velthuis AJW. Influenza virus RNA synthesis and the innate immune response［J］. Viruses, 2021, 13(5): 780.
［11］姚张峰, 张学明, 马晓慧. rhGCSF治疗小儿中性粒细胞减少症的临床效果［J］. 中国妇幼健康研究, 2019, 30(1): 61-64.
［12］Theyab A, Algahtani M, Alsharif KF, et al. New insight into the mechanism of granulocyte colonystimulating factor (GCSF) that induces the mobilization of neutrophils［J］. Hematology, 2021, 26(1): 628-636.
|
|
|
|
