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Abstract Objective: To analyse the changes of selfreferential network （SRN）and cerebrospinal fluid pathological markers amyloid βprotein （Aβ）, total tau （ttau） and phosphorylated tau （p-tau） for patients with amnestic mild cognitive impairment（aMCI）. Methods: A total of 51 aMCI patients were enrolled in the study. According to the cognitive awareness index, they were divided into the aMCI group with impaired cognitive awareness（n=20）and the aMCI group（n=31）with cognitive awareness preserved. All patients underwent resting functional magnetic resonance （rsfMRI）, lumbar puncture, and cognitive assessment. Independent component analysis was used to extract SRN; two-sample t test was used to explore the functional connectivity of SRN and cerebrospinal fluid （Aβ, ttau and ptau）changes; Pearson correlation analysis was used to explore the relationship between cognitive awareness index and functional connectivity changes and the levels of cerebrospinal fluid Aβ, t-tau and p-tau. Results: The aMCI group with impaired cognitive awareness showed hyperconnectivity in the bilateral medial orbitofrontal cortex, left anterior cingulate gyrus and right rectus gyrus （AlphaSim correction, P<0.001, voxel number>17）. The difference in brain function connectivity between the two groups was negatively correlated with the cognitive awareness index（r=-0.457, P<0.000）. The level of Aβ in cerebrospinal fluid in the aMCI group with impaired cognitive awareness was significantly lower than that of the aMCI group with cognitive awareness preserved（P<0.01）, ptau and ttau in cerebrospinal fluid were significantly increased than those of the aMCI group with cognitive awareness preserved（P<0.001）. The cerebrospinal fluid Aβ level was positively correlated with cognitive awareness index（r=0.331, P=0.025）, and cerebrospinal fluid t-tau and p-tau levels were negatively correlated with cognitive consciousness index （r=-0.534,-0.508, both P<0.001）. Conclusion: SRN is the neuroimaging basis of cognitive awareness; aMCI patients with impaired cognitive awareness have impaired functional connectivity of SRN and more severe deposition of Alzheimer′s disease pathological markers.

Received: 05 January 2021

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	Articles by authors
	CHEN Shanshan1
	CHEN Jiu2
	XU Wenwen1
	SONG Yu1
	LIN Xingjian1

Cite this article:

CHEN Shanshan1,CHEN Jiu2,XU Wenwen1等. Effect of impaired cognitive awareness on the characteristics of self-referential network and pathological markers in amnestic mild cognitive impairment patients[J]. Journal of Jiangsu University(Medicine Edition), 2021, 31(02): 108-113.

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2021/V31/I02/108

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