SATB2在结直肠腺癌肝转移中的表达及其诊断价值

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Abstract Objective: To investigate the diagnostic and differential value of special AT-rich sequencebinding protein 2(SATB2) in colorectal adenocarcinoma and combined detection of SATB2 with cytokeratin20 (CK20) and caudalrelated homeodomain transcription 2 (CDX2) in hepatic metastasis of colorectal adenocarcinoma. Methods: Immunohistochemical staining was used to detect the expression of SATB2 in 100 cases of colorectal adenocarcinoma and 234 cases of other types of adenocarcinoma; and the expression of SATB2, CK20 and CDX2 in 5 different types of 179 cases adenocarcinoma tissues was detected. The sensitivity, specificity and accuracy of SATB2, CK20 and CDX2 were analyzed, respectively. Results: The positive expression rate of SATB2 in colorectal adenocarcinoma (89%) was significantly higher than that in other types of adenocarcinoma(1.28%,χ2=270.107,P<0.001). The positive expression rate of SATB2 in liver cancer tissues derived from colorectal adenocarcinoma metastasis was 84.00%, while only 2.33% in patients with noncolorectal adenocarcinoma metastasis. The expression sensitivity, specificity and accuracy were as follows: SATB2 was 84.00%, 97.67% and 93.85%; CK20 was 76.00%, 77.52% and 77.09%; CDX2 was 98.00%, 67.44% and 75.98%. Conclusion: The positive expression rate of SATB2 in colorectal adenocarcinoma was high. Its combination with CK20 and CDX2 could be used to differentiate and diagnose liver metastasis of colorectal adenocarcinoma.

Received: 06 May 2019

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2019/V29/I05/410

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