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| Effect of the GABAergic neuron activity of entorhinal cortex on sensorimotor gating and active avoidance learning in rats |
| FENG Chi1, LI Guo-hai2, WANG Jia1, JIANG Yang1, WANG Yu-cong1， XIAO Xu1,
LI Cong1, FAN Zun1, XU Jia-dan1, WANG Lei1, ZHANG Wei-ning1,2 |
| (1. School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013; 2. Mental Health Center of Zhenjiang, Zhenjiang Jiangsu 212005，China) |
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Abstract [Abstract\]Objective: To investigate the effect of GABAergic neuron activity of entorhinal cortex in rats on sensorimotor gating and active avoidance learning. Methods: Bilaterally implanted guide cannulae into the medial entorhinal cortex(MEC) or lateral entorhinal cortex(LEC), the rats were infused with GABAA receptor agonist muscimol(1 μg/μL, 0.5 μL per hemisphere) or saline. The behavioral tests were conducted 30 min after infusion. Results: After muscimol infusion, compared with the saline infused control group, the rats in MEC group showed hyperactivity in the open filed test, more entries into the open and closed arm in the elevated plusmaze test and disruption of the prepulse inhibition at intensity of 73 dB, as well as the deficiency of learning and memory in the twoway active avoidance task. Conclusion: The entorhinal cortical neuronal activity, especial the medial entorhinal cortex area, plays important roles in the spontaneous activity, anxiety, sensorimotor gating, as well as the twoway active avoidance learning and memory of rats.
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Received: 11 April 2017
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2017, Vol. 27 
