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Abstract Objective： To investigate usefulness of neutrophil CD64 index as a marker to differentiate between infection and disease flare in patients with rheumatoid arthritis (RA). Methods：The peripheral blood specimens from 24 RA patients with active stage, 20 RA patients with stable stage, 18 RA patients with infection and 30 healthy controls were collected. Neutrophil CD64 index was quantitatively measured using flow cytometry. The correlation between neutrophil CD64 index and laboratory data in RA patients was analyzed. The sensitivity and specificity of neutrophil CD64 index in diagnosis of RA with infection was calculated by receiver operating characteristic curve. Results：Neutrophil CD64 index in RA patients with infection (8.23±3.39) were significantly higher than active stage RA patients \[(2.61±0.94), P<0.001\], stable stage RA patients \[(1.78±0.76), P<0.001\] and healthy controls \[(1.65±0.61), P<0.001\]. The expression of neutrophil CD64 index was positively correlated with WBC in RA patients with infection (r=0.462， P=0.037). Although neutrophil CD64 index in infection patients with Gram negative bacilli was higher than Gram positive coccus, there was no statistical difference ［(9.06±3.39) vs (6.07±2.50), t=1.782, P=0.094］. The sensitivity and specificity of neutrophil CD64 index in diagnosis of infection in RA patients was 94.4% and 91.7%, respectively. Conclusion：Neutrophil CD64 index may be a marker to differentiate between infection and disease flare in patients with RA.
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Received: 27 May 2016
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2016, Vol. 26 
