Effect of resting metabolic rate on peripheral neuropathy in patients with type 2 diabetes
SHI Li 1,2, LIU Xuekui 1,3, XU Wei 1,3, GENG Houfa 1, SANG Yiquan 1, LI Yinxia 1, LIANG Jun 1,3
(1. Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Jiangsu 221009; 2. Xuzhou Institute of Medical Sciences, Xuzhou Jiangsu 221006; 3. Xuzhou Institute of Diabetes Mellitus, Xuzhou Jiangsu 221006, China)
Abstract：Objective： To study the correlation between resting metabolic rate (RMR) and diabetic peripheral neuropathy (DPN) in adult patients with type 2 diabetes mellitus（T2DM）, and to evaluate the modifying effects of BMI, waist circumference, neck circumference, waist-to-hip ratio and body fat on the correlationship. Methods： A total of 416 patients with type 2 diabetes were selected and divided into two groups: single T2DM group and T2DM+DPN group. The subjects′ height, body weight, waist circumference, neck circumference, hip circumference, and nerve conduction velocity were measured, and the blood lipid, blood pressure, fasting insulin, blood glucose, HbAlc, and other biochemical indicators were examined. Mifflin-St-Jeor formula was used to calculate RMR, and RMR was stratified by the quartile method. The Logistic regression model was used to analyze the relationship between RMR and DPN. Waist circumference, hip circumference, waist-to-hip ratio, and bady fat data were stratified into three grades, and multiple stepwise Logistic regression analyses were applied to analyze the effects of RMR on DPN at different levels. Results： The risk of DPN decreased with the increase of RMR level in T2DM (P<0.05). Stratified analysis showed that RMR had significant effect on DPN when waist circumference<90 cm or>98 cm, neck circumference>101 cm, waist-to-hip ratio<0.92 and body fat<24.8%（all P<0.05）. When T2DM was complicated with obesity, the risk of DPN was decreased following with the increasing RMR (P<0.05) and there was an interaction (P=0.021). Conclusion：RMR of T2DM patients is associated with DPN, and the higher the RMR, the lower the risk of DPN.
［Key words］type 2 diabetes mellitus; resting metabolic rate; diabetic peripheral neuropathy；obesity；interaction
收稿日期: 2022-02-21
基金资助:中国内分泌代谢英才研究项目（2021-N-03）；徐州市科技局课题（KC18195）
通讯作者:
梁军（通讯作者），主任医师，博士，E-mail：mwlg521@163.com
作者简介: 拾莉（1974—），女，副主任医师，硕士；
引用本文:
拾莉， 刘学奎， 徐伟，等.. 静息代谢率对2型糖尿病患者合并周围神经病变的影响[J]. 江苏大学学报:医学版, 2022, 32(06): 515-519，523.
SHI Li, LIU Xuekui, XU Wei,et al.. Effect of resting metabolic rate on peripheral neuropathy in patients with type 2 diabetes. Journal of Jiangsu University(Medicine Edition), 2022, 32(06): 515-519，523.
