自噬调控与阿尔茨海默病相关的分子机制研究进展

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摘要阿尔茨海默病（Alzheimer′s disease, AD）是以渐进性减退和逐渐恶化的认知功能障碍为主要临床特征的神经退行性疾病，伴有全脑萎缩现象并有β淀粉样蛋白和tau蛋白出现。自噬是一种保守且溶酶体依赖的过程，在此过程中细胞器和多种蛋白被降解、回收并重新利用。自噬功能缺陷可能会导致AD患者脑区毒性蛋白聚集且不能降解。本文对自噬及其与AD相关的机制和调控基因进行阐述。

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	马思飞1
	郭美娜1
	刘文君1
	史厚珍1
	翟鸿儒1
	张维宁1
	钱进军1
	2
	3
	王佳1
	2
	3
	刘子重2

关键词 ：自噬, 阿尔茨海默病, &beta, -淀粉样蛋白, tau蛋白

收稿日期: 2020-11-11

基金资助: 国家自然科学基金资助项目（81671053）；江苏省第五期“333”科研项目（BRA2019171）；江苏省高层次卫生人才“六个一工程”拔尖人才（LGY2017025）；镇江市重点研发社会发展面上项目（SH2019059，SH2018074）

通讯作者: 王佳（通讯作者），副教授，博士生导师，E-mail：wangjia@ujs.edu.cn；刘子重（通讯作者），副教授，硕士生导师，E-mail：492151523@qq.com

作者简介: 马思飞（1994—），女，硕士研究生

引用本文:

马思飞1，郭美娜1，刘文君1，史厚珍1，翟鸿儒1，张维宁1，钱进军1,2,3，王佳1,2,3，刘子重2. 自噬调控与阿尔茨海默病相关的分子机制研究进展[J]. 江苏大学学报:医学版, 2021, 31(02): 120-123, 128.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2021/V31/I02/120

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