微透析技术在药动学及药动学药效学模型研究中的应用进展

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摘要目的: 微透析作为近年来新兴的一种活体取样技术，克服了传统取样存在的动物数量较多、前处理过程复杂、不能准确反映成分在机体内实时变化、不能准确测定游离药物浓度等缺点，具有活体、实时、靶向、连续取样等特点，能更真实地反映药物在机体吸收、分布、代谢、排泄的过程，在药动学及药动学药效学（PKPD）结合模型的研究中被广泛应用。本文对微透析技术在药动学及PKPD研究中的应用进行综述，以期为药物的体内过程、作用机制以及靶向性研究提供参考。

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	胡贺佳1
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	3
	陈艳4
	王爱民1
	2
	3
	王永林1
	2
	3
	巩仔鹏1
	2
	3

关键词 ：微透析技术, 活体取样, 药动学, 药动学药效学（PK-PD）

收稿日期: 2020-11-16

基金资助:国家自然科学基金资助项目(81703661，81860734，U1812403)；中央引导地方科技专项项目(黔科中引地［2018］4006)

通讯作者: 巩仔鹏（通讯作者），博士，教授，硕士生导师，E-mail：gzp4012607@126.com

作者简介: 胡贺佳（1996—），女，硕士研究生

引用本文:

胡贺佳1,2,3，陈艳4，王爱民1,2,3，王永林1,2,3，巩仔鹏1,2,3. 微透析技术在药动学及药动学药效学模型研究中的应用进展[J]. 江苏大学学报:医学版, 2021, 31(01): 44-50.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2021/V31/I01/44

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