Abstract：Objective: To analyze the therapeutic efficacy of single-dose regimen of methotrexate(MTX) in the treatment of low-risk non-metastatic gestational trophoblastic tumor(GTT). Methods: A total of 105 patients with low-risk and non-metastatic gestational trophoblastic tumor were enrolled, and were divided into two groups to analyze the efficacy of chemotherapy and the incidence of adverse reaction according to their own will. Sixty patients were voluntarily adopted with single dose of MTX(single-dose group), and the other 45 patients were voluntarily adopted with multi course of MTX(multi-course group). Results: There was no significant difference in complete remission rate,drug resistance rate, recurrence rate and mean time from start to complete remission between the single-dose group and multi-course group.However,the average course of chemotherapy in the single-dose group(1.90±1.48) was significantly less than those in the multi-course group(4.93±2.46, P<0.05).The leucopenia, nausea/vomiting and mucositis rate of the single-dose group was significantly lower than those of multi-course group (3.33% vs 28.89%,10.00% vs 33.33%, 11.67% vs 28.89%, P<0.05). Conclusion: Single-dose MTX chemotherapy has a short course of chemotherapy and a low incidence of side effects, may be an effective option for women with low-risk and non-metastatic gestational trophoblastic tumor.
［Key words］low-risk and non-metastatic gestational trophoblastic tumor; methotrexate; chemotherapy
收稿日期: 2018-03-26
基金资助:
无锡市医学重点学科建设项目（ZDXKJS001）
通讯作者:
蒋倩颖（通讯作者），医师，E-mail:jqyn@163.com
作者简介: 杭晨（1978—），女，江苏泰州人，副主任医师，主要从事妇科肿瘤临床研究；
引用本文:
杭晨， 赵绍杰， 蒋倩颖. 甲氨蝶呤单疗程治疗低危无转移妊娠滋养细胞肿瘤的疗效分析[J]. 江苏大学学报:医学版, 2018, 28(06): 507-.
HANG Chen, ZHAO Shao-jie, JIANG Qian-ying. Analysis of therapeutic efficacy of single-dose methotrexate chemotherapy in low-risk and non-metastatic gestational trophoblastic tumor. Journal of Jiangsu University(Medicine Edition), 2018, 28(06): 507-.
2018, Vol. 28 
