SiO2@Fe3O4复合纳米微球的合成及其对盐酸表柔比星的载药性能

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摘要目的: 制备新型磁性纳米微球SiO₂@Fe₃O₄，并考察其对盐酸表柔比星的载药性能。方法: 以水热法制备的Fe3O4作为核，无水乙醇和水为共溶剂，一定浓度的氨水为催化剂，通过正硅酸四乙酯（tetraethyl orthosilicate,TEOS）的水解与缩合制备SiO₂@Fe₃O₄复合纳米微球，通过X射线衍射（XRD）法、透射电子显微镜（TEM）、红外吸收光谱（FT-IR）等测试样品的物相与结构，通过外加磁场测试其磁响应性，并通过药物吸附和缓释实验检测该纳米微球对表柔比星的载药性能。结果：当V（TEOS）=0.8 mL，V（氨水）=1.25 mL，V(水) ∶V（无水乙醇）=1 ∶5时，SiO2在Fe3O4微球表面包覆均匀完整，厚度约为60 nm。药物吸附实验显示，制备的SiO₂@Fe₃O₄复合纳米微球对表柔比星的吸附率为51.9%，磁响应性、体外稳定性和缓释效果均较好。结论：新型磁性纳米微球SiO2@Fe3O4能有效吸附和缓释表柔比星，具有良好的磁响应性，可作为靶向纳米药物载体。

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关键词 ：盐酸表柔比星, SiO₂@Fe₃O₄, 靶向药物载体

Abstract：Objective: To synthetize a new magnetic SiO2@Fe3O4 nanoparticles and evaluate the performance of SiO2@Fe3O4 for the epirubicin hydrochloride delivery. Methods: Using the Fe3O4 nanoparticles prepared by hydrothermal method as the magnetic foundation, the magnetic SiO2@Fe3O4 nanoparticles were prepared by hydrolysis and condensation of tetraethyl orthosilicate(TEOS). The microstructure and properties of the samples were characterized by Xray diffraction(XRD) method, transmission electron microscopy(TEM) and Fourier transform infrared spectroscopy(FTIR).The magnetic responsiveness of SiO2@Fe3O4 nanoparticles was tested through magnetic field. The property of SiO2@Fe3O4 nanoparticles for the controlled release of epirubicin was evaluated. Results: The thickness of the SiO2 layer was nearly 60 nm when V(TEOS)=0.8 mL, V(ammonia)=1.25 mL and V(water) ∶V(alcohol)=1 ∶5. The entrapment efficiency of epirubicin hydrochloride was 51.9 % and the products presented good dispersity and excellent stability. Conclusion: The magnetic SiO2@Fe3O4 nanoparticles could adsorb and delayedly release the epirubicin effectively. The SiO2@Fe3O4 nanocarriers displayed favorable magnetic responsiveness and have application prospects in the field of drug targeted nanocarriers.

收稿日期: 2017-12-26

基金资助:

镇江市工业支撑项目（GY2010020）

作者简介: 吴玲（1982—），女，江苏南京人，主管技师，主要从事药剂学研究。

引用本文:

吴玲1，徐箐2，李娣2，姜德立2，陈敏2. SiO₂@Fe₃O₄复合纳米微球的合成及其对盐酸表柔比星的载药性能[J]. 江苏大学学报:医学版, 2018, 28(02): 169-173. WU Ling1, XU Qing2, LI Di2, JIANG De-li2, CHEN Min2. Synthesis of SiO₂@Fe₃O₄ composite nanoparticles for the controlled release of epirubicin hydrochloride. Journal of Jiangsu University(Medicine Edition), 2018, 28(02): 169-173.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2018/V28/I02/169

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