Value of exploratory eye movement examination in the diagnosis of mild cognitive impairment and early-stage Alzheimer disease
GU Jun1,2, LI Guo-hai3, LIU Xiao-wei2, XU Qing2, ZHU Hong-mei2
（1. School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013; 2. Department of Geriatric Psychiatry, Wuxi Mental Health Center, Wuxi Jiangsu 214151; 3. Department of Psychiatry, Zhenjiang Mental Health Center, Zhenjiang Jiangsu 212005, China）
Abstract：bjective: To study the value of exploratory eye movement examination in the diagnosis of mild cognitive impairment or earlystage Alzheimer disease(earlystage AD). Methods: The subjects were divided into three groups: individuals with mild cognitive impairment(MCI), patients with earlystage AD, and normal controls, with 30 cases in each group.All the subjects were evaluated with the Montreal Cognitive Assessment(MoCA) and underwent exploratory eye movement examination. The measures of exploratory eye movements include number of eye fixation(NEF),responsive search score(RSS) and discriminant analysis value(D value). The measures of exploratory eye movements were compared among three groups, and the associations between MoCA scores and the eye movement measures were examined. Results: There were statistically significant differences in NEF,RSS,and D value among the three groups(P＜0.01).MoCA scores were positively correlated with NEF and RSS(P＜0.01) and were negatively correlated with D value(P＜0.01) in MCI group and earlystage AD group. Conclusion: Exploratory eye movement examination may be used in distinguishingindividuals with MCI or earlystage AD,and the measures of exploratory eye movement may reflect the severity of cognitive impairment.
顾君1,2, 李国海3， 刘晓伟2， 徐清2, 朱红梅2. 探究性眼球轨迹运动对轻度认知功能障碍和早期阿尔茨海默病的诊断价值[J]. 江苏大学学报:医学版, 2017, 27(02): 146-149.
GU Jun1,2, LI Guo-hai3, LIU Xiao-wei2, XU Qing2, ZHU Hong-mei2. Value of exploratory eye movement examination in the diagnosis of mild cognitive impairment and early-stage Alzheimer disease. Journal of Jiangsu University(Medicine Edition), 2017, 27(02): 146-149.
[1\]高中宝,王炜,赵杏丽,等.老年轻度认知功能损害患者认知水平的随访研究\[J\].中华医学杂志,2011,91(1):37-39.\[2\]Alichniewicz KK,Brunner F,Klünemann HH,et al. Neural correlates of saccadic inhibition in healthy elderly and patients with amnestic mild cognitive impairment\[J\]. Front Psychol,2013,4:467.\[3\]Tales A, Snowden RJ, Haworth J, et al. Abnormal spatial and nonspatial cueing effects in mild cognitive impairment and Alzheimer′s disease\[J\].Neurocase,2005,11(1):85-92.\[4\]Rozzini L, Chilovi BV, Conti M, et al. Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration\[J\].Int J Geriatr Psychiatry,2007,22(12):1217-1222.\[5\]赵虎,周运宝,吕怀宝,等.衰退期与非衰退期男性精神分裂症患者探究性眼球轨迹运动及认知功能的比较\[J\].临床精神医学杂志,2014,24(3):189-190.\[6\]Pereira ML,Camarqo Mv,Aprahamian I,et al.Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer′s disease\[J\]. Neuropsychiatr Dis Treat,2014,10:1273-1285.\[7\]Anderson TJ,MacAskill MR.Eye movements in patients with neurodegenerative disorders\[J\]. Nat Rev Neurol,2013,9(2):74-85.\[8\]程艳,肖世富.中国轻度认知功能损害研究进展\[J\].上海精神医学,2014,26(1):3-11.\[9\]Mosimann UP, Felblinger J, Ballinari P, et al. Visual exploration behavior during clock reading in Alzheimer′s disease\[J\].Brain,2004,127(2):431-438.\[10\]Nakashima Y, Morita K, Ishii Y, et al. Characteristics of exploratory eye movements in elderly people: possibility of early diagnosis of dementia\[J\]. Psychogeriatrics, 2010,10(3):124-130.\[11\]孟晓梅,于逢春,尹静,等.蒙特利尔认知评估量表用于轻度认知功能障碍患者评估的初步研究\[J\].中华老年心脑血管病杂志,2012,14(11):1173-1175.
2017, Vol. 27 
