Abstract：Objective: To investigate the relationships between CA19-9 and CA24-2 levels and estradiol levels in the serum in female physiological periods. Methods: CA19-9 and CA24-2 and estradiol levels were detected in the serum in different physical period of 150 females, then the relationships between CA19-9 and CA24-2 levels and estradiol levels were analysed, and 150 males were used as controls. Results: The CA19-9 and CA24-2 levels in females serum were obviously higher than those of controls, respectively(t=4.848，P<0.001； t=8.11，P<0.001). The positive rate of CA199 and CA242 in females serum were also obviously higher than those of controls (χ2=6.621，P=0.010 1； χ2=8.219，P=0.004 1). There were obvious differences between the CA19-9 levels and CA24-2 levels in different physical period of females, respectively (F=10.53，P<0.001; F=12.61，P<0.001,). The CA19-9 levels and CA24-2 levels were negative correlations with that of estradiol levels in the serum of female, the equations were Y=－0.027 01X+38.62 (r2=0.523 9， P<0.001) and Y=－0.016 88X+ 23.40 (r2=0.653 1， P<0.001), respectively. Ten women with high CA19-9 and CA24-2 levels were followed up 5 years, the result showed that CA19-9 and CA242 levels almost decreased to normal after 6 months. Conclusion: The elevation of serum CA19-9 and CA24-2 levels in woman are not malignant and in connection with physical period of female.
收稿日期: 2014-05-24
作者简介: 安仙园（1980—），女，安徽铜陵人，主管技师，主要从事临床检验工作。
引用本文:
安仙园. 女性血清CA19-9,CA24-2水平与雌二醇变化的关系[J]. 江苏大学学报:医学版, 2014, 24(04): 316-319.
AN Xian-yuan. Relationships between CA19-9， CA24-2 levels and estradiol change in serum of normal female. Journal of Jiangsu University(Medicine Edition), 2014, 24(04): 316-319.
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2014, Vol. 24 
