Abstract：Sudden cardiac death(SCD) is a leading cause for sudden death, which is characterized by rapid progression and no omen before the onset of disease. Therefore, it is of great value clinically to identify the patients with high risk of SCD. With the deepening of research, the relationship between cardiac repolarization abnormality and SCD has been gradually revealed. This paper briefly describes the relationship between the manifestations of cardiac repolarization abnormality and SCD, and the underlying mechanisms.
[1] Aro AL, Anttonen O, Tikkanen JT, et al. Prevalence and prognostic significance of Twave inversions in right precordial leads of a 12lead electrocardiogram in the middleaged subjects [J]. Circulation, 2012, 125(21): 2572-2577.[2] Laukkanen JA, Di Angelantonio E, Khan H, et al. Twave inversion, QRS duration, and QRS/T angle as electrocardiographic predictors of the risk for sudden cardiac death [J]. Am J Cardiol , 2014, 113(7): 1178-1183.[3] Cuddy TE, Tate RB. Sudden unexpected cardiac death as a function of time since the detection of electrocardiographic and clinical risk factors in apparently healthy men: the Manitoba FollowUp Study, 1948 to 2004 [J]. Can J Cardiol , 2006, 22(3): 205-211.[4] Pavri BB, Hillis MB, Subacius H, et al. Prognostic value and temporal behavior of the planar QRST angle in patients with nonischemic cardiomyopathy [J]. Circulation, 2008, 117(25): 3181-3186.[5] Bay s de Luna A, Coumel P, Leclercq JF. Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases[J]. Am Heart J , 1989, 117(1): 151-159.[6] Schwartz PJ, Moss AJ, Vincent GM, et al. Diagnostic criteria for the long QT syndrome. An update [J]. Circulation, 1993, 88(2): 782-784.[7] Shimizu W, Aiba T, Antzelevitch C. Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome[J]. Curr Pharm Des , 2005, 11(12): 1561-1572.[8] Antzelevitch C, Yan GX, Shimizu W. Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome[J]. J Electrocardiol, 1999, 32 Suppl: 158-165.[9] Antzelevitch C, Shimizu W, Yan GX,et al. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart [J]. J Cardiovasc Electrophysiol, 1999, 10(8)：1124-1152.[10] Strom M, Wan X, Poelzing S, et al. Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall [J]. Am J Physiol Heart Circ Physiol, 2010, 298(3): H787-H794.[11] Meijborg VM, Chauveau S, Janse MJ, et al. Interventricular dispersion in repolarization causes bifid T waves in dogs with dofetilideinduced long QT syndrome [J]. Heart Rhythm, 2015, 12(6): 1343-1351.[12] Yan GX, Antzelevitch C. Cellular basis for the electrocardiographic J wave [J]. Circulation, 1996, 93(2): 372-379.[13] Patocskai B, Antzelevitch C. Novel therapeutic strategies for the management of ventricular arrhythmias associated with the Brugada syndrome [J]. Expert Opinion on Orphan Drugs, 2015, 3(6): 633-651.[14] Nademanee K, Raju H, de Noronha SV, et al. Fibrosis, Connexin43, and Conduction Abnormalities in the Brugada Syndrome [J]. J Am Coll Cardiol , 2015, 66(18): 1976-1986.[15] Coronel R,Casini S,Koopmann TT,et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugadasyndrome:a combined electrophysiological, genetic, histopathologic, and computationalstudy[J]. Circulation,2005,112(18): 2769-2777.[16] Hoogendijk MG, Potse M, Linnenbank AC, et al. Mechanism of right precordial STsegment elevation in structural heart disease: excitation failure by currenttoload mismatch [J]. Heart Rhythm, 2010, 7(2): 238-248.[17] Kawata H, Noda T, Yamada Y, et al. Effect of sodiumchannel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome[J]. Heart Rhythm, 2012, 9(1):77-83.[18] Wu SH, Lin XX, Cheng YJ, et al. Early repolarization pattern and risk for arrhythmia death: a meta-analysis[J]. J Am Coll Cardiol, 2013, 61(6): 645-650.[19] Tikkanen JT, Junttila MJ, Anttonen O, et al. Early repolarization electrocardiographic phenotypes associated with favorable longterm outcome [J]. Circulation, 2011, 123(23): 2666-2673.
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