Abstract：Objective To explore the predictive value of glucose-regulated protein 94 (GRP94) and transforming growth factor-β1 (TGF-β1) levels for long-term recurrence events in patients with atrial fibrillation (AF) after ablation. Methods A total of 202 inpatients undergoing radiofrequency ablation for AF were selected and uniformly attributed to AF group. They were further divided into paroxysmal AF group (n=132) and persistent AF group (n=70) according to the occurrence time and duration of AF. Healthy subjects with sinus rhythm and previously without AF rhythm were selected as control group (n=55). Serum GRP94 and TGF-β1 levels were measured by enzyme linked immunosorbent assay and the enrolled patients’ baseline data were collected. After discharge, patients with AF were followed up in the outpatient department or by telephone. Receiver operating characteristic curve and Kaplan-Meier survival analysis were used to evaluate the value of serum GRP94 and TGF-β1 levels in predicting long-term recurrence events in AF patients after ablation. Results Serum GRP94 and TGF-β1 levels of the control group, paroxysmal AF group and persistent AF group increase in turn. Binary Logistic regression analysis suggests that serum TGF-β1, GRP94 and body mass index are independent risk factors for AF. Spearman correlation analysis shows a positive correlation between serum GRP94 and TGF-β1 levels in AF patients. The TGF-β1 level of the recurrence group is higher than that of the non-recurrence group while the GRP94 level of the recurrence group is lower than that of the non-recurrence group. Binary Logistic regression analysis shows that TGF-β1 is an independent risk factor for postoperative recurrence of AF while GRP94 is an independent protective factor. Analysis of KaplanMeier curve shows that AF patients with high GRP94 level and low TGF-β1 level have a lower risk of recurrence after ablation, and longer duration without recurrence. Conclusion GRP94 and TGF-β1 levels are closely related to AF, which probably provides references for the early identification, diagnosis and prevention of recurrent AF after operation.
路桥，张先林，王洪巨，黄宇理，史晓俊，李妙男，张恒. 葡萄糖调节蛋白94和转化生长因子-β1与房颤患者预后的相关性[J]. 实用心电学杂志, 2023, 32(2): 115-122.
LU Qiao, ZHANG Xianlin, WANG Hongju, HUANG Yuli, SHI Xiaojun, LI Miaonan, ZHANG Heng. Relativity between glucose-regulated protein 94, transforming growth factor-β1 and prognosis of patients with atrial fibrillation. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2023, 32(2): 115-122.
