Abstract：Pulmonary hypertension (PH) is a progressive disease characterized by vascular stiffness and altered cellular metabolism. The progressive remodeling of the pulmonary arteries in PH patients causes progressive elevation of pulmonary vascular resistance, eventually leading to right heart failure and even death. Although PH has been extensively studied, the exact pathogenesis has not been fully elucidated. In recent years, studies have found that the metabolic changes of pulmonary vascular cells are related to the pathogenesis of PH, and abnormal metabolism of pulmonary vascular cells (such as smooth muscle cells and endothelial cells) is present in PH patients. The metabolic changes of these cells may result in damage of pulmonary vascular cell and pulmonary vascular remodeling. This article reviews the role metabolic changes of pulmonary vascular cells plays in the development of PH.
虎梅，李德红，苏红玲，高锦霞，曹云山. 肺高血压与细胞代谢[J]. 实用心电学杂志, 2021, 30(4): 229-234.
HU Mei1,2, LI Dehong3, SU Hongling2,GAO Jinxia4, CAO Yunshan2. Pulmonary hypertension and cellular metabolism. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2021, 30(4): 229-234.
