Based on Navier-Stokes equations and standard k-ε turbulence model, the threedimensional turbulent flow in a centrifugal pump with space guide vanes was numerically simulated by using a SIMPLEC algorithm. The internal flow field of a centrifugal pump with entire flow, annular space and space guide vanes under design condition was analyzed, and the experiment was carried out to examine the simulation results. The results showed that the pressure of suction surface of impeller blades near the inlet area was lowest and negative pressure appeared. Higher impact loss was found in the annular space between impeller and space guide vanes. The highspeed rotating fluid from impeller outlet flowed into the guide vanes through annular space, the velocity near the inlet of space guide vanes was high, and there existed secondary flow near the leading edge of the space guide vane suction surface. The calculation and experimental results coincided well, and the maximum error was less than 15% between the numerical calculation results and experimental data under the same flow，which was in the acceptable limits and proved the effectiveness of numerical calculation. The research results provide a theoretical reference for geometric parameters optimization of the space guide vanes.
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