排灌机械工程学报
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排灌机械工程学报  2019, Vol. 37 Issue (1): 1-6    DOI: 10.3969/j.issn.1674-8530.17.0191
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可控关闭体积心脏瓣膜模型
贺照明,刘艳芳,荆腾,张桂杰,刘洪艳,王颢
1. 江苏大学国家水泵及系统工程技研究中心,江苏 镇江 212013; 2. 德州理工大学机械工程系,德克萨斯州 拉伯克 79409
Heart valve model with controllable closing volume
HE Zhaoming, LIU Yanfang, JING Teng, ZHANG Guijie, LIU Hongyan, WANG Hao
1.National Research Center of Pumps, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2.Department of Mechanical Engineering, Texas Tech University, Lubbock, Texas 79409,USA
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摘要 为了准确描述心脏瓣膜血液动力学特性及其在心血管系统中的应用,根据电液比拟,将其建模为1个变电阻和1个电流源并联然后和1个恒电感串联的瓣膜模型,并建立了左心循环系统的电路图及数学方程.并联元件把流经瓣膜的血流量分成2部分:流经瓣膜孔口的流量和瓣叶运动过程中排挤的血流量.流阻依赖瓣叶位置,另外给定符合关闭体积和时间的瓣叶关闭过程.以二尖瓣为例进行Matlab数值模拟,结果表明:该模型能准确模拟瓣膜关闭反流和泄漏体积的反流特性,正常情况下心脏每搏输出量63.60 mL,心输出量4.58 L/min,二尖瓣关闭体积为3.30 mL,二尖瓣泄漏体积为2.30 mL,反流分数为7.56%;反流病理条件下,二尖瓣关闭体积为14.70 mL,泄漏体积为25.40 mL,反流分数为40.48%.该模型可以模拟瓣膜正常功能和反流病理的血液动力学.
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贺照明
刘艳芳
荆腾
张桂杰
刘洪艳
王颢
关键词心脏瓣膜   关闭体积   泄漏体积   反流模型   左心血液循环     
Abstract: In order to accurately describe hemodynamics of heart valve and its application in the cardiovascular system, this paper modeled the heart valve as a variable resistor and a current source in parallel and then a constant inductance in series according to electricliquid analogy. The governing equations of the left ventricular circulation were derived. The heart valve model divided the flow into two branches: flow through valve orifice and flow displaced by valve leaflets. The resistance depends on leaflet position and the heart valve closing motion was controlled with specified closing volume. For the mitral valve, Matlab was used to solve these equations to obtain circulation hemodynamics, which reflected the closing and leaking characteristics of the heart valve. The closing and leakage volumes were 3.30 mL and 2.30 mL, respectively, at stroke volume 63.60 mL or the normal cardiac output 4.58 L/min. The closing and leakage volumes were 14.70 mL and 25.40 mL, respectively, at the mitral regurgitation. This model can be used to simulate hemodynamics of the normal and regurgitated heart valve and thus arterial hemodynamics.
Key wordsheart valve   closing volume   leakage volume   regurgitation model   left heart circulates   
收稿日期: 2017-08-19;
基金资助:

国家自然科学基金资助项目(31600794); 江苏省高层次创新创业人才引进计划基金资助项目; 江苏省特聘教授计划基金资助项目; 江苏省自然科学基金资助项目(BK20130539)

引用本文:   
贺照明,刘艳芳,荆腾等. 可控关闭体积心脏瓣膜模型[J]. 排灌机械工程学报, 2019, 37(1): 1-6.
HE Zhao-Ming,LIU Yan-Fang,JING Teng et al. Heart valve model with controllable closing volume[J]. Journal of Drainage and Irrigation Machinery Engin, 2019, 37(1): 1-6.
 
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